Our Research
How do crypts Form?
Our overarching hypothesis is that the architecture of the intestinal stem cell niche is a key component of the niche. Its stereotypic shape plays a role in proper niche function. In order to test this hypothesis, we need to first understand the process of crypt morphogenesis (Dev Cell, 2018).
What are crypts good for?
Crypts have such stereotypic shapes and sizes. Within a region of the intestine, crypts roughly contain the same number of cells, are about the same length and have about the same diameter. How do they regulate this? Does this stereotypic shape regulate stem cell dynamics, signaling gradients? We want to know!
what else supports a crypt?
The intestinal stroma is full of different cell types. Do any of these other cells contribute to crypt architecture or function? Do they regulate crypt morphogenesis or homeostasis?
